Lead optimization of novel quinolone chalcone compounds by a structure–activity relationship (SAR) study to increase efficacy and metabolic stability

por James Knockleby, Aïcha Dede Djigo, Indeewari Kalhari Lindamulage, Chandrabose Karthikeyan, Piyush Trivedi, Hoyun Lee
Publicado 2021

Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank

por David A. Kolin, Scott Kulm, Olivier Elemento
Publicado 2021

An mCARE study on patterns of risk and resilience for children with ASD in Bangladesh

por Masud Rabbani, Munirul M. Haque, Dipranjan Das Dipal, Md Ishrak Islam Zarif, Anik Iqbal, Amy Schwichtenberg, Naveen Bansal, Tanjir Rashid Soron, Syed Ishtiaque Ahmed, Sheikh Iqbal Ahamed
Publicado 2021

Peptide barcoding for one-pot evaluation of sequence–function relationships of nanobodies

por Yusei Matsuzaki, Wataru Aoki, Takumi Miyazaki, Shunsuke Aburaya, Yuta Ohtani, Kaho Kajiwara, Naoki Koike, Hiroyoshi Minakuchi, Natsuko Miura, Tetsuya Kadonosono, Mitsuyoshi Ueda
Publicado 2021

Fungal infections lead to shifts in thermal tolerance and voluntary exposure to extreme temperatures in both prey and predator insects

por Mitzy F. Porras, Gustavo A. Agudelo-Cantero, M. Geovanni Santiago-Martínez, Carlos A. Navas, Volker Loeschcke, Jesper Givskov Sørensen, Edwin G. Rajotte
Publicado 2021

Metabolomic profiling of Burkholderia cenocepacia in synthetic cystic fibrosis sputum medium reveals nutrient environment-specific production of virulence factors

por Olakunle A. Jaiyesimi, Andrew C. McAvoy, David N. Fogg, Neha Garg
Publicado 2021

Prevalence and risk factors of type-2 diabetes mellitus in Ethiopia: systematic review and meta-analysis

por Melkamu A. Zeru, Endalamaw Tesfa, Aweke A. Mitiku, Awoke Seyoum, Tesfaye Abera Bokoro
Publicado 2021

Functional disruption of cell wall invertase inhibitor by genome editing increases sugar content of tomato fruit without decrease fruit weight

por Kohei Kawaguchi, Rie Takei-Hoshi, Ikue Yoshikawa, Keiji Nishida, Makoto Kobayashi, Miyako Kusano, Yu Lu, Tohru Ariizumi, Hiroshi Ezura, Shungo Otagaki, Shogo Matsumoto, Katsuhiro Shiratake
Publicado 2021

A pre-formulation study of tetracaine loaded in optimized nanostructured lipid carriers

por Simone R. Castro, Lígia N. M. Ribeiro, Márcia C. Breitkreitz, Viviane A. Guilherme, Gustavo H. Rodrigues da Silva, Hery Mitsutake, Ana C. S. Alcântara, Fabiano Yokaichiya, Margareth K. K. D. Franco, Daniel Clemens, Ben Kent, Marcelo Lancellotti, Daniele R. de Araújo, Eneida de Paula
Publicado 2021

Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells

por Akram Rahmani, Fariborz Rahimi, Mehrdad Iranshahi, Houman Kahroba, Amir Zarebkohan, Mehdi Talebi, Roya Salehi, Hassan Zavvar Mousavi
Publicado 2021

Targeting IFN activity to both B cells and plasmacytoid dendritic cells induces a robust tolerogenic response and protection against EAE

por Anje Cauwels, Sandra Van Lint, Elke Rogge, Annick Verhee, Bram Van Den Eeckhout, Shengru Pang, Marco Prinz, Niko Kley, Gilles Uzé, Jan Tavernier
Publicado 2021

The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex

por Jayarjun Ethiraj, Thulani Hansika Palpagama, Clinton Turner, Bert van der Werf, Henry John Waldvogel, Richard Lewis Maxwell Faull, Andrea Kwakowsky
Publicado 2021

Author Correction: Long-term potentiation of glycinergic synapses by semi-natural stimulation patterns during tonotopic map refinement

por Eva C. Bach, Karl Kandler
Publicado 2021

Comparisons of physical activity and understanding of the importance of exercise according to dialysis modality in maintenance dialysis patients

por Jun Chul Kim, Jun Young Do, Seok Hui Kang
Publicado 2021

Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein

por Maciej Gielnik, Michał Taube, Lilia Zhukova, Igor Zhukov, Sebastian K. T. S. Wärmländer, Željko Svedružić, Wojciech M. Kwiatek, Astrid Gräslund, Maciej Kozak
Publicado 2021

Robotic fabrication of high-quality lamellae for aberration-corrected transmission electron microscopy

por Hideyo Tsurusawa, Nobuto Nakanishi, Kayoko Kawano, Yiqiang Chen, Mikhail Dutka, Brandon Van Leer, Teruyasu Mizoguchi
Publicado 2021

Learning exceptions to the rule in human and model via hippocampal encoding

por Emily M. Heffernan, Margaret L. Schlichting, Michael L. Mack
Publicado 2021

Improved production of the non-native cofactor F420 in Escherichia coli

por Mihir V. Shah, Hadi Nazem-Bokaee, James Antoney, Suk Woo Kang, Colin J. Jackson, Colin Scott
Publicado 2021

Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences

por Christopher R. Corbeil, Mahder Seifu Manenda, Traian Sulea, Jason Baardsnes, Marie-Ève Picard, Hervé Hogues, Francis Gaudreault, Christophe Deprez, Rong Shi, Enrico O. Purisima
Publicado 2021

Home advantage mediated (HAM) by referee bias and team performance during covid

por Merim Bilalić, Bartosz Gula, Nemanja Vaci
Publicado 2021