Ca2+/CaM binding to CaMKI promotes IMA-3 importin binding and nuclear translocation in sensory neurons to control behavioral adaptation

por Domenica Ippolito, Saurabh Thapliyal, Dominique A Glauser
Publicado 2021

PARROT is a flexible recurrent neural network framework for analysis of large protein datasets

por Daniel Griffith, Alex S Holehouse
Publicado 2021

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

por Kathryn P Trogden, Justin Lee, Kai M Bracey, Kung-Hsien Ho, Hudson McKinney, Xiaodong Zhu, Goker Arpag, Thomas G Folland, Anna B Osipovich, Mark A Magnuson, Marija Zanic, Guoqiang Gu, William R Holmes, Irina Kaverina
Publicado 2021

A novel live-cell imaging assay reveals regulation of endosome maturation

por Maria Podinovskaia, Cristina Prescianotto-Baschong, Dominik P Buser, Anne Spang
Publicado 2021

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

por Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen, Owen J Sansom, Onno Kranenburg, Riccardo Fodde
Publicado 2021

Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

por Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Nicole Fischer, Sakibul Huq, Adham M Khalafallah, Marco Trevisan, Pär Sparen, Juan J Carrero, Akihiko Nishimura, Brian Caffo, Elizabeth A Stuart, Renyuan Bai, Verena Staedtke, David L Thomas, Nickolas Papadopoulos, Ken W Kinzler, Bert Vogelstein, Shibin Zhou, Chetan Bettegowda, Maximilian F Konig, Brett D Mensh, Joshua T Vogelstein, Susan Athey
Publicado 2021

Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo

por Taisuke Miyazaki, Megumi Morimoto-Tomita, Coralie Berthoux, Kotaro Konno, Yoav Noam, Tokiwa Yamasaki, Matthijs Verhage, Pablo E Castillo, Masahiko Watanabe, Susumu Tomita
Publicado 2021

A prion accelerates proliferation at the expense of lifespan

por David M Garcia, Edgar A Campbell, Christopher M Jakobson, Mitsuhiro Tsuchiya, Ethan A Shaw, Acadia L DiNardo, Matt Kaeberlein, Daniel F Jarosz
Publicado 2021

Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

por Solène N Lefebvre, Antoine Taly, Anaïs Menny, Karima Medjebeur, Pierre-Jean Corringer
Publicado 2021

Do wealth and inequality associate with health in a small-scale subsistence society?

por Adrian V Jaeggi, Aaron D Blackwell, Christopher von Rueden, Benjamin C Trumble, Jonathan Stieglitz, Angela R Garcia, Thomas S Kraft, Bret A Beheim, Paul L Hooper, Hillard Kaplan, Michael Gurven
Publicado 2021

Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

por Louis Shekhtman, Miquel Navasa, Natasha Sansone, Gonzalo Crespo, Gitanjali Subramanya, Tje Lin Chung, E Fabian Cardozo-Ojeda, Sofía Pérez-del-Pulgar, Alan S Perelson, Scott J Cotler, Xavier Forns, Susan L Uprichard, Harel Dahari
Publicado 2021

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

por James A Watson, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C George, Kathryn Maitland, Nicholas PJ Day, Arjen M Dondorp, Philip Bejon, Thomas N Williams, Chris C Holmes, Nicholas J White
Publicado 2021

Neurovascular coupling and bilateral connectivity during NREM and REM sleep

por Kevin L Turner, Kyle W Gheres, Elizabeth A Proctor, Patrick J Drew
Publicado 2020

Visually induced changes in cytokine production in the chick choroid

por Jody A Summers, Elizabeth Martinez
Publicado 2021

scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

por Bilge E Öztürk, Molly E Johnson, Michael Kleyman, Serhan Turunç, Jing He, Sara Jabalameli, Zhouhuan Xi, Meike Visel, Valérie L Dufour, Simone Iwabe, Luis Felipe L Pompeo Marinho, Gustavo D Aguirre, José-Alain Sahel, David V Schaffer, Andreas R Pfenning, John G Flannery, William A Beltran, William R Stauffer, Leah C Byrne
Publicado 2021

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

por Shannon Rausser, Caroline Trumpff, Marlon A McGill, Alex Junker, Wei Wang, Siu-Hong Ho, Anika Mitchell, Kalpita R Karan, Catherine Monk, Suzanne C Segerstrom, Rebecca G Reed, Martin Picard
Publicado 2021

The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity

por Chad W Sauvola, Yulia Akbergenova, Karen L Cunningham, Nicole A Aponte-Santiago, J Troy Littleton
Publicado 2021

Biomarkers in a socially exchanged fluid reflect colony maturity, behavior, and distributed metabolism

por Sanja M Hakala, Marie-Pierre Meurville, Michael Stumpe, Adria C LeBoeuf
Publicado 2021

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

por Harvey Perez, May F Abdallah, Jose I Chavira, Angelina S Norris, Martin T Egeland, Karen L Vo, Callan L Buechsenschuetz, Valentina Sanghez, Jeannie L Kim, Molly Pind, Kotoka Nakamura, Geoffrey G Hicks, Richard A Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J McKinnon, Paul J Mathews
Publicado 2021

Distinct higher-order representations of natural sounds in human and ferret auditory cortex

por Agnès Landemard, Célian Bimbard, Charlie Demené, Shihab Shamma, Sam Norman-Haignere, Yves Boubenec
Publicado 2021