Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction

por Fabio Da Silva, Fariba Jian Motamedi, Lahiru Chamara Weerasinghe Arachchige, Amelie Tison, Stephen T Bradford, Jonathan Lefebvre, Pascal Dolle, Norbert B Ghyselinck, Kay D Wagner, Andreas Schedl
Publicado 2021

An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

por Lei Guo, Xin-yu Fan, Xiaomu Qiao, Craig Montell, Jia Huang
Publicado 2021

Characterizing human mobility patterns in rural settings of sub-Saharan Africa

por Hannah R Meredith, John R Giles, Javier Perez-Saez, Théophile Mande, Andrea Rinaldo, Simon Mutembo, Elliot N Kabalo, Kabondo Makungo, Caroline O Buckee, Andrew J Tatem, C Jessica E Metcalf, Amy Wesolowski
Publicado 2021

Circuits for integrating learned and innate valences in the insect brain

por Claire Eschbach, Akira Fushiki, Michael Winding, Bruno Afonso, Ingrid V Andrade, Benjamin T Cocanougher, Katharina Eichler, Ruben Gepner, Guangwei Si, Javier Valdes-Aleman, Richard D Fetter, Marc Gershow, Gregory SXE Jefferis, Aravinthan DT Samuel, James W Truman, Albert Cardona, Marta Zlatic
Publicado 2021

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

por Joanna L Gillis, Josephine A Hinneh, Natalie K Ryan, Swati Irani, Max Moldovan, Lake-Ee Quek, Raj K Shrestha, Adrienne R Hanson, Jianling Xie, Andrew J Hoy, Jeff Holst, Margaret M Centenera, Ian G Mills, David J Lynn, Luke A Selth, Lisa M Butler
Publicado 2021

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

por Astrid Kollewe, Vladimir Chubanov, Fong Tsuen Tseung, Leonor Correia, Eva Schmidt, Anna Rössig, Susanna Zierler, Alexander Haupt, Catrin Swantje Müller, Wolfgang Bildl, Uwe Schulte, Annette Nicke, Bernd Fakler, Thomas Gudermann
Publicado 2021

APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

por Angela R Garcia, Caleb Finch, Margaret Gatz, Thomas Kraft, Daniel Eid Rodriguez, Daniel Cummings, Mia Charifson, Kenneth Buetow, Bret A Beheim, Hooman Allayee, Gregory S Thomas, Jonathan Stieglitz, Michael D Gurven, Hillard Kaplan, Benjamin C Trumble
Publicado 2021

The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood–brain barrier formation and maturation

por Xiaoling Li, Richard Fetter, Tina Schwabe, Christophe Jung, Liren Liu, Hermann Steller, Ulrike Gaul
Publicado 2021

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

por Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra
Publicado 2021

Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates

por Shan Zhou, Weiwei Wang, Xiaoting Zhou, Yuying Zhang, Yuezheng Lai, Yanting Tang, Jinxu Xu, Dongmei Li, Jianping Lin, Xiaolin Yang, Ting Ran, Hongming Chen, Luke W Guddat, Quan Wang, Yan Gao, Zihe Rao, Hongri Gong
Publicado 2021

Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

por Ella Podvalny, Leana E King, Biyu J He
Publicado 2021

Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome

por Isabelle J Marié, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele V Baracho, Azlann Arnett, Haiyan S Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S Watowich, Bernard Khor, David E Levy
Publicado 2021

Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

por David L Hocker, Carlos D Brody, Cristina Savin, Christine M Constantinople
Publicado 2021

Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

por Austin R Graves, Richard H Roth, Han L Tan, Qianwen Zhu, Alexei M Bygrave, Elena Lopez-Ortega, Ingie Hong, Alina C Spiegel, Richard C Johnson, Joshua T Vogelstein, Daniel J Tward, Michael I Miller, Richard L Huganir
Publicado 2021

Fibrinogen αC-subregions critically contribute blood clot fibre growth, mechanical stability, and resistance to fibrinolysis

por Helen R McPherson, Cedric Duval, Stephen R Baker, Matthew S Hindle, Lih T Cheah, Nathan L Asquith, Marco M Domingues, Victoria C Ridger, Simon DA Connell, Khalid M Naseem, Helen Philippou, Ramzi A Ajjan, Robert AS Ariëns
Publicado 2021

Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

por Elisabeth Gludovacz, Kornelia Schuetzenberger, Marlene Resch, Katharina Tillmann, Karin Petroczi, Markus Schosserer, Sigrid Vondra, Serhii Vakal, Gerald Klanert, Jürgen Pollheimer, Tiina A Salminen, Bernd Jilma, Nicole Borth, Thomas Boehm
Publicado 2021

Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer

por Marinus Huber, Kosmas V Kepesidis, Liudmila Voronina, Frank Fleischmann, Ernst Fill, Jacqueline Hermann, Ina Koch, Katrin Milger-Kneidinger, Thomas Kolben, Gerald B Schulz, Friedrich Jokisch, Jürgen Behr, Nadia Harbeck, Maximilian Reiser, Christian Stief, Ferenc Krausz, Mihaela Zigman
Publicado 2021

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

por Axel A Guzmán-Solís, Viridiana Villa-Islas, Miriam J Bravo-López, Marcela Sandoval-Velasco, Julie K Wesp, Jorge A Gómez-Valdés, María de la Luz Moreno-Cabrera, Alejandro Meraz, Gabriela Solís-Pichardo, Peter Schaaf, Benjamin R TenOever, Daniel Blanco-Melo, María C Ávila Arcos
Publicado 2021

A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

por Xiao Zhang, Hero Robles, Kristann L Magee, Madelyn R Lorenz, Zhaohua Wang, Charles A Harris, Clarissa S Craft, Erica L Scheller
Publicado 2021

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

por Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss
Publicado 2021