Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

par Luke F. Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S. Jardetzky
Publié 2021

Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

par Luke F. Pennington, Svetlana Tarchevskaya, Daniel Brigger, Karthik Sathiyamoorthy, Michelle T. Graham, Kari Christine Nadeau, Alexander Eggel, Theodore S. Jardetzky
Publié 2016

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

par Pascal Gasser, Svetlana S. Tarchevskaya, Pascal Guntern, Daniel Brigger, Rahel Ruppli, Noemi Zbären, Silke Kleinboelting, Christoph Heusser, Theodore S. Jardetzky, Alexander Eggel
Publié 2020