A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

por Nicolas Bery, Ami Miller, Terry Rabbitts
Publicado 2020

Pan RAS-binding compounds selected from a chemical library by inhibiting interaction between RAS and a reduced affinity intracellular antibody

por Tomoyuki Tanaka, Jemima Thomas, Rob Van Montfort, Ami Miller, Terry Rabbitts
Publicado 2021

Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins

por Adam Leach, Ami Miller, Emma Bentley, Giada Mattiuzzo, Jemima Thomas, Craig McAndrew, Rob Van Montfort, Terence Rabbitts
Publicado 2021

A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection

por Ami Miller, Adam Leach, Jemima Thomas, Craig McAndrew, Emma Bentley, Giada Mattiuzzo, Lijo John, Ali Mirazimi, Gemma Harris, Nadisha Gamage, Stephen Carr, Hanif Ali, Rob Van Montfort, Terence Rabbitts
Publicado 2021

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

por Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publicado 2019

Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

por Camilo E. Quevedo, Abimael Cruz-Migoni, Nicolas Bery, Ami Miller, Tomoyuki Tanaka, Donna Petch, Carole J. R. Bataille, Lydia Y. W. Lee, Phillip S. Fallon, Hanna Tulmin, Matthias T. Ehebauer, Narcis Fernandez-Fuentes, Angela J. Russell, Stephen B. Carr, Simon E. V. Phillips, Terence H. Rabbitts
Publicado 2018