Directed evolution for high functional production and stability of a challenging G protein-coupled receptor

por Yann Waltenspühl, Jeliazko R. Jeliazkov, Lutz Kummer, Andreas Plückthun
Publicado 2021

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

por Jendrik Schöppe, Janosch Ehrenmann, Christoph Klenk, Prakash Rucktooa, Marco Schütz, Andrew S. Doré, Andreas Plückthun
Publicado 2019

Asymmetric requirement of Dpp/BMP morphogen dispersal in the Drosophila wing disc

por Shinya Matsuda, Jonas V. Schaefer, Yusuke Mii, Yutaro Hori, Dimitri Bieli, Masanori Taira, Andreas Plückthun, Markus Affolter
Publicado 2021

Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization

por Jakob C. Stüber, Christian P. Richter, Junel Sotolongo Bellón, Martin Schwill, Iwo König, Benjamin Schuler, Jacob Piehler, Andreas Plückthun
Publicado 2021

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

por Rastislav Tamaskovic, Martin Schwill, Gabriela Nagy-Davidescu, Christian Jost, Dagmar C. Schaefer, Wouter P. R. Verdurmen, Jonas V. Schaefer, Annemarie Honegger, Andreas Plückthun
Publicado 2016

A survival selection strategy for engineering synthetic binding proteins that specifically recognize post-translationally phosphorylated proteins

por Bunyarit Meksiriporn, Morgan B. Ludwicki, Erin A. Stephens, Allen Jiang, Hyeon-Cheol Lee, Dujduan Waraho-Zhmayev, Lutz Kummer, Fabian Brandl, Andreas Plückthun, Matthew P. DeLisa
Publicado 2019

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

por Tariq Afroz, Eva-Maria Hock, Patrick Ernst, Chiara Foglieni, Melanie Jambeau, Larissa A. B. Gilhespy, Florent Laferriere, Zuzanna Maniecka, Andreas Plückthun, Peer Mittl, Paolo Paganetti, Frédéric H. T. Allain, Magdalini Polymenidou
Publicado 2017

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

por Markus Schmid, Patrick Ernst, Annemarie Honegger, Maarit Suomalainen, Martina Zimmermann, Lukas Braun, Sarah Stauffer, Cristian Thom, Birgit Dreier, Matthias Eibauer, Anja Kipar, Viola Vogel, Urs F. Greber, Ohad Medalia, Andreas Plückthun
Publicado 2018

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

por Florian Kast, Martin Schwill, Jakob C. Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M. Monné Rodríguez, Frauke Seehusen, Christian P. Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G. Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Publicado 2021

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

por Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun, Alexandra Trkola
Publicado 2021