Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

por Chiara Maniaci, Scott J. Hughes, Andrea Testa, Wenzhang Chen, Douglas J. Lamont, Sonia Rocha, Dario R. Alessi, Roberto Romeo, Alessio Ciulli
Publicado 2017

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

por Elton Zeqiraj, Beatrice Maria Filippi, Simon Goldie, Iva Navratilova, Jérôme Boudeau, Maria Deak, Dario R Alessi, Daan M F van Aalten
Publicado 2009

Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains

por Aida M. Lopez-Guerrero, Patricia Tomas-Martin, Carlos Pascual-Caro, Thomas Macartney, Alejandro Rojas-Fernandez, Graeme Ball, Dario R. Alessi, Eulalia Pozo-Guisado, Francisco Javier Martin-Romero
Publicado 2017

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.

por Nicolas Dzamko, Francisco Inesta-Vaquera, Jiazhen Zhang, Chengsong Xie, Huaibin Cai, Simon Arthur, Li Tan, Hwanguen Choi, Nathanael Gray, Philip Cohen, Patrick Pedrioli, Kristopher Clark, Dario R Alessi
Publicado 2012