Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

por Dominik Hoelper, Hongda Huang, Aayushi Y. Jain, Dinshaw J. Patel, Peter W. Lewis
Publicado 2017

Structural basis underlying viral hijacking of a histone chaperone complex

por Hongda Huang, Zhong Deng, Olga Vladimirova, Andreas Wiedmer, Fang Lu, Paul M. Lieberman, Dinshaw J. Patel
Publicado 2016

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

por Luqian Zheng, Elisabeth Mairhofer, Marianna Teplova, Ye Zhang, Jinbiao Ma, Dinshaw J. Patel, Ronald Micura, Aiming Ren
Publicado 2017

Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

por Xiawei Huang, Hongmiao Hu, Alexandre Webster, Fan Zou, Jiamu Du, Dinshaw J. Patel, Ravi Sachidanandam, Katalin Fejes Toth, Alexei A. Aravin, Sisi Li
Publicado 2021

Correction: Structural basis of phosphatidylcholine recognition by the C2-Domain of cytosolic phospholipase A2α

por Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown
Publicado 2021

Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

por Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown
Publicado 2019

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

por Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publicado 2017

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

por Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publicado 2017

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

por Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Publicado 2019

DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation

por Wendan Ren, Huitao Fan, Sara A. Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P. Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Çetin, Dinshaw J. Patel, Yinsheng Wang, Qiang Cui, Brian D. Strahl, Or Gozani, Kyle M. Miller, Seán E. O’Leary, Paul A. Wade, Gang Greg Wang, Jikui Song
Publicado 2021

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

por Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Publicado 2019