Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

by Melissa F. Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V. Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M. Ashcroft
Published 2016

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse.

by Fiona McMurray, Chris D Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y C Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S H Yeo, Stephen O'Rahilly, Frances M Ashcroft, Anthony P Coll, Roger D Cox
Published 2013

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

by Elizabeth Haythorne, Maria Rohm, Martijn van de Bunt, Melissa F. Brereton, Andrei I. Tarasov, Thomas S. Blacker, Gregor Sachse, Mariana Silva dos Santos, Raul Terron Exposito, Simon Davis, Otto Baba, Roman Fischer, Michael R. Duchen, Patrik Rorsman, James I. MacRae, Frances M. Ashcroft
Published 2019

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

by Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Published 2019

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5.

by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker
Published 2013