Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

por Kamal R. Abdul Azeez, Sneha Chatterjee, Channing Yu, Todd R. Golub, Frank Sobott, Jonathan M. Elkins
Publicado 2019

A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT

por Ariel Talavera, Hedvig Tamman, Andres Ainelo, Albert Konijnenberg, San Hadži, Frank Sobott, Abel Garcia-Pino, Rita Hõrak, Remy Loris
Publicado 2019

Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

por Anna J. Higgins, Alex J. Flynn, Anaïs Marconnet, Laura J. Musgrove, Vincent L. G. Postis, Jonathan D. Lippiat, Chun-wa Chung, Tom Ceska, Manuela Zoonens, Frank Sobott, Stephen P. Muench
Publicado 2021

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

por Amberley D. Stephens, Maria Zacharopoulou, Rani Moons, Giuliana Fusco, Neeleema Seetaloo, Anass Chiki, Philippa J. Woodhams, Ioanna Mela, Hilal A. Lashuel, Jonathan J. Phillips, Alfonso De Simone, Frank Sobott, Gabriele S. Kaminski Schierle
Publicado 2020

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

por Javier Lizarrondo, David P. Klebl, Stephan Niebling, Marc Abella, Martin A. Schroer, Haydyn D. T. Mertens, Katharina Veith, Roland Thuenauer, Dmitri I. Svergun, Michal Skruzny, Frank Sobott, Stephen P. Muench, Maria M. Garcia-Alai
Publicado 2021

A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

por Egon Deyaert, Lina Wauters, Giambattista Guaitoli, Albert Konijnenberg, Margaux Leemans, Susanne Terheyden, Arsen Petrovic, Rodrigo Gallardo, Laura M. Nederveen-Schippers, Panagiotis S. Athanasopoulos, Henderikus Pots, Peter J. M. Van Haastert, Frank Sobott, Christian Johannes Gloeckner, Rouslan Efremov, Arjan Kortholt, Wim Versées
Publicado 2017