Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides.

por Yoko Ota, Hiroyuki Yoda, Takahiro Inoue, Takayoshi Watanabe, Yoshinao Shinozaki, Atsushi Takatori, Hiroki Nagase
Publicado 2021

MCT4 is induced by metastasis-enhancing pathogenic mitochondrial NADH dehydrogenase gene mutations and can be a therapeutic target

por Keizo Takenaga, Nobuko Koshikawa, Miho Akimoto, Yasutoshi Tatsumi, Jason Lin, Makiko Itami, Hiroki Nagase
Publicado 2021

Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment

por Yoshiyasu Kitagawa, Kazuhiro Okumura, Takayoshi Watanabe, Kei Tsukamoto, Shiro Kitano, Rino Nankinzan, Takuto Suzuki, Taro Hara, Hiroaki Soda, Tadamichi Denda, Taketo Yamaguchi, Hiroki Nagase
Publicado 2019

Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties

por Yuya Terashima, Etsuko Toda, Meiji Itakura, Mikiya Otsuji, Sosuke Yoshinaga, Kazuhiro Okumura, Francis H. W. Shand, Yoshihiro Komohara, Mitsuhiro Takeda, Kana Kokubo, Ming-Chen Chen, Sana Yokoi, Hirofumi Rokutan, Yutaka Kofuku, Koji Ohnishi, Miki Ohira, Toshihiko Iizasa, Hirofumi Nakano, Takayoshi Okabe, Hirotatsu Kojima, Akira Shimizu, Shiro Kanegasaki, Ming-Rong Zhang, Ichio Shimada, Hiroki Nagase, Hiroaki Terasawa, Kouji Matsushima
Publicado 2020