Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

por Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout
Publicado 2020

Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis

por Chen-Hsueh Pai, Shu-Rung Lin, Chia-Hao Liu, Szu-Yu Pan, Hao Hsu, Yi-Ting Chen, Ching-Tzu Yen, I-Shing Yu, Hua-Lin Wu, Shuei-Liong Lin, Shu-Wha Lin
Publicado 2020

The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation

por Chih-Yuan Lee, Ting-Yu Lai, Meng-Kun Tsai, Yung-Chi Chang, Yu-Hsin Ho, I-Shing Yu, Tzu-Wen Yeh, Chih-Chang Chou, You-Sheng Lin, Toby Lawrence, Li-Chung Hsu
Publicado 2017

Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation

por Chia-Ching Lin, Yi-Ru Shen, Chi-Chih Chang, Xiang-Yi Guo, Yun-Yun Young, Ting-Yu Lai, I-Shing Yu, Chih-Yuan Lee, Tsung-Hsien Chuang, Hsin-Yue Tsai, Li-Chung Hsu
Publicado 2021

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

por Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty, Li-Fan Lu
Publicado 2018

A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.

por Shiu-Huey Chou, Bor-Sheng Ko, Ji-Shain Chiou, Yueh-Chwen Hsu, Mong-Hsun Tsai, Yu-Chiao Chiu, I-Shing Yu, Shu-Wha Lin, Hsin-An Hou, Yi-Yi Kuo, Hsiu-Mei Lin, Ming-Fang Wu, Wen-Chien Chou, Hwei-Fang Tien
Publicado 2012