Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape

por Nicholas C. Wu, Jakub Otwinowski, Andrew J. Thompson, Corwin M. Nycholat, Armita Nourmohammad, Ian A. Wilson
Publicado 2020

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth <italic toggle="yes">In Vivo</italic>

por Rui Xu, Samantha G. Palmer, Matteo Porotto, Laura M. Palermo, Stefan Niewiesk, Ian A. Wilson, Anne Moscona
Publicado 2013

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity

por Ralph Pantophlet, Nino Trattnig, Sasha Murrell, Naiomi Lu, Dennis Chau, Caitlin Rempel, Ian A. Wilson, Paul Kosma
Publicado 2017

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

por Jens C. Krause, Damian C. Ekiert, Terrence M. Tumpey, Patricia B. Smith, Ian A. Wilson, James E. Crowe
Publicado 2011

Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide

por Sonu Kumar, Anita Sarkar, Pavel Pugach, Rogier W. Sanders, John P. Moore, Andrew B. Ward, Ian A. Wilson
Publicado 2019

Exploration of uncharted regions of the protein universe.

por Lukasz Jaroszewski, Zhanwen Li, S Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M Deacon, Ian A Wilson, Adam Godzik
Publicado 2009

Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past

por Jeffery K. Taubenberger, David Baltimore, Peter C. Doherty, Howard Markel, David M. Morens, Robert G. Webster, Ian A. Wilson
Publicado 2012

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

por Nicholas C. Wu, Geramie Grande, Hannah L. Turner, Andrew B. Ward, Jia Xie, Richard A. Lerner, Ian A. Wilson
Publicado 2017

Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification

por Senlian Hong, Yujie Shi, Nicholas C. Wu, Geramie Grande, Lacey Douthit, Hua Wang, Wen Zhou, K. Barry Sharpless, Ian A. Wilson, Jia Xie, Peng Wu
Publicado 2019

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

por Nicholas C. Wu, Andrew J. Thompson, Jia Xie, Chih-Wei Lin, Corwin M. Nycholat, Xueyong Zhu, Richard A. Lerner, James C. Paulson, Ian A. Wilson
Publicado 2018

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

por Yasunori Watanabe, Zachary T. Berndsen, Jayna Raghwani, Gemma E. Seabright, Joel D. Allen, Oliver G. Pybus, Jason S. McLellan, Ian A. Wilson, Thomas A. Bowden, Andrew B. Ward, Max Crispin
Publicado 2020

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

por Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Gonzalo Gonzalez-Paez, Zhen Han, Katherine L. Williams, Wayne Volkmuth, Daniel Emerling, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson
Publicado 2021

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

por Linling He, Anshul Chaudhary, Xiaohe Lin, Cindy Sou, Tanwee Alkutkar, Sonu Kumar, Timothy Ngo, Ezra Kosviner, Gabriel Ozorowski, Robyn L. Stanfield, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Publicado 2021

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

por Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Publicado 2016

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles

por Sonu Kumar, Xiaohe Lin, Timothy Ngo, Benjamin Shapero, Cindy Sou, Joel D. Allen, Jeffrey Copps, Lei Zhang, Gabriel Ozorowski, Linling He, Max Crispin, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Publicado 2021

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

por Kathrin Koch, Sarah Kalusche, Jonathan L. Torres, Robyn L. Stanfield, Welbeck Danquah, Kamal Khazanehdari, Hagen von Briesen, Eric R. Geertsma, Ian A. Wilson, Ulrich Wernery, Friedrich Koch-Nolte, Andrew B. Ward, Ursula Dietrich
Publicado 2017

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

por Linling He, Natalia de Val, Charles D. Morris, Nemil Vora, Therese C. Thinnes, Leopold Kong, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Ian A Wilson, David Nemazee, Andrew B. Ward, Jiang Zhu
Publicado 2016

Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

por Timothy J. C. Tan, Meng Yuan, Kaylee Kuzelka, Gilberto C. Padron, Jacob R. Beal, Xin Chen, Yiquan Wang, Joel Rivera-Cardona, Xueyong Zhu, Beth M. Stadtmueller, Christopher B. Brooke, Ian A. Wilson, Nicholas C. Wu
Publicado 2021

Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

por Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson
Publicado 2018

Novel lamprey antibody recognizes terminal sulfated galactose epitopes on mammalian glycoproteins

por Tanya R. McKitrick, Steffen M. Bernard, Alexander J. Noll, Bernard C. Collins, Christoffer K. Goth, Alyssa M. McQuillan, Jamie Heimburg-Molinaro, Brantley R. Herrin, Ian A. Wilson, Max D. Cooper, Richard D. Cummings
Publicado 2021