The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

par Olli Matilainen, Maroun S. Bou Sleiman, Pedro M. Quiros, Susana M. D. A. Garcia, Johan Auwerx
Publié 2017

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections

par Eleonora Ciarlo, Tytti Heinonen, Jérôme Lugrin, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Publié 2017

Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells.

par Delphine Balmer, Martine Emery, Pénélope Andreux, Johan Auwerx, Vanessa Ginet, Julien Puyal, Daniel F Schorderet, Raphaël Roduit
Publié 2013

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

par Nicola Vannini, Mukul Girotra, Olaia Naveiras, Gennady Nikitin, Vasco Campos, Sonja Giger, Aline Roch, Johan Auwerx, Matthias P. Lutolf
Publié 2016

PPARγ controls Dectin-1 expression required for host antifungal defense against Candida albicans.

par Amandine Galès, Annabelle Conduché, José Bernad, Lise Lefevre, David Olagnier, Maryse Béraud, Guillaume Martin-Blondel, Marie-Denise Linas, Johan Auwerx, Agnès Coste, Bernard Pipy
Publié 2010

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

par Joanna Ratajczak, Magali Joffraud, Samuel A. J. Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S. Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E. Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó
Publié 2016

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

par Kristine Williams, Lars R. Ingerslev, Jette Bork-Jensen, Martin Wohlwend, Ann Normann Hansen, Lewin Small, Rasmus Ribel-Madsen, Arne Astrup, Oluf Pedersen, Johan Auwerx, Christopher T. Workman, Niels Grarup, Torben Hansen, Romain Barrès
Publié 2020

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

par Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T. Yu, Annette R. Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M. Evans, Qibin Leng
Publié 2017

Autophagy regulates lipid metabolism through selective turnover of NCoR1

par Tetsuya Saito, Akiko Kuma, Yuki Sugiura, Yoshinobu Ichimura, Miki Obata, Hiroshi Kitamura, Shujiro Okuda, Hyeon-Cheol Lee, Kazutaka Ikeda, Yumi Kanegae, Izumu Saito, Johan Auwerx, Hozumi Motohashi, Makoto Suematsu, Tomoyoshi Soga, Takehiko Yokomizo, Satoshi Waguri, Noboru Mizushima, Masaaki Komatsu
Publié 2019

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

par Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C. Lucchini, Rémy Denzler, Muriel C. Fisser, Tenagne D. Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A. O’Reilly, Markus Stoffel, Johan Auwerx, Daniel Konrad
Publié 2017

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers

par Aaron F. McDaid, Peter K. Joshi, Eleonora Porcu, Andrea Komljenovic, Hao Li, Vincenzo Sorrentino, Maria Litovchenko, Roel P. J. Bevers, Sina Rüeger, Alexandre Reymond, Murielle Bochud, Bart Deplancke, Robert W. Williams, Marc Robinson-Rechavi, Fred Paccaud, Valentin Rousson, Johan Auwerx, James F. Wilson, Zoltán Kutalik
Publié 2017

Reduced oxidative capacity in macrophages results in systemic insulin resistance

par Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W. Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx, Minho Shong
Publié 2018

Joint mouse–human phenome-wide association to test gene function and disease risk

par Xusheng Wang, Ashutosh K. Pandey, Megan K. Mulligan, Evan G. Williams, Khyobeni Mozhui, Zhengsheng Li, Virginija Jovaisaite, L. Darryl Quarles, Zhousheng Xiao, Jinsong Huang, John A. Capra, Zugen Chen, William L. Taylor, Lisa Bastarache, Xinnan Niu, Katherine S. Pollard, Daniel C. Ciobanu, Alexander O. Reznik, Artem V. Tishkov, Igor B. Zhulin, Junmin Peng, Stanley F. Nelson, Joshua C. Denny, Johan Auwerx, Lu Lu, Robert W. Williams
Publié 2016