Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors.

por Wouter Wegdam, Carmen A Argmann, Gertjan Kramer, Johannes P Vissers, Marrije R Buist, Gemma G Kenter, Johannes M F G Aerts, Danielle Meijer, Perry D Moerland
Publicado 2014

Renal involvement in a patient with the chronic visceral subtype of acid sphingomyelinase deficiency resembles Fabry disease

por Eline C. B. Eskes, Martijn J. C. van derLienden, Joris J. T. H. Roelofs, Liffert Vogt, Johannes M. F. G. Aerts, Jan Aten, Carla E. M. Hollak
Publicado 2021

Long-term effect of antibodies against infused alpha-galactosidase A in Fabry disease on plasma and urinary (lyso)Gb3 reduction and treatment outcome.

por Saskia M Rombach, Johannes M F G Aerts, Ben J H M Poorthuis, Johanna E M Groener, Wilma Donker-Koopman, Erik Hendriks, Mina Mirzaian, Sijmen Kuiper, Frits A Wijburg, Carla E M Hollak, Gabor E Linthorst
Publicado 2012

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.

por Elisa Lombardo, Cindy P A A van Roomen, Gijs H van Puijvelde, Roelof Ottenhoff, Marco van Eijk, Jan Aten, Johan Kuiper, Herman S Overkleeft, Albert K Groen, Arthur J Verhoeven, Johannes M F G Aerts, Florence Bietrix
Publicado 2012

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.

por Silvie Timmers, Johan de Vogel-van den Bosch, Matthijs K C Hesselink, Denis van Beurden, Gert Schaart, Maria Joao Ferraz, Mario Losen, Pilar Martinez-Martinez, Marc H De Baets, Johannes M F G Aerts, Patrick Schrauwen
Publicado 2011

Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

por Marco van Eijk, Jan Aten, Nora Bijl, Roelof Ottenhoff, Cindy P A A van Roomen, Peter F Dubbelhuis, Ingar Seeman, Karen Ghauharali-van der Vlugt, Hermen S Overkleeft, Cynthia Arbeeny, Albert K Groen, Johannes M F G Aerts
Publicado 2009

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.

por Karen M Ashe, Dinesh Bangari, Lingyun Li, Mario A Cabrera-Salazar, Scott D Bercury, Jennifer B Nietupski, Christopher G F Cooper, Johannes M F G Aerts, Edward R Lee, Diane P Copeland, Seng H Cheng, Ronald K Scheule, John Marshall
Publicado 2011