Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms

por Yan Zhang, Maria H. Ulvmar, Lukas Stanczuk, Ines Martinez-Corral, Maike Frye, Kari Alitalo, Taija Mäkinen
Publicado 2018

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

por Riikka Kivelä, Ida Salmela, Yen Hoang Nguyen, Tatiana V. Petrova, Heikki A. Koistinen, Zoltan Wiener, Kari Alitalo
Publicado 2016

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

por Sawan Kumar Jha, Khushbu Rauniyar, Terhi Karpanen, Veli-Matti Leppänen, Pascal Brouillard, Miikka Vikkula, Kari Alitalo, Michael Jeltsch
Publicado 2017

Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice.

por Momina Mirza, Mei-Fong Pang, Mohamad Amr Zaini, Paula Haiko, Tuomas Tammela, Kari Alitalo, Lennart Philipson, Jonas Fuxe, Kerstin Sollerbrant
Publicado 2012

Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.

por Sonja Koopal, Johanna H Furuhjelm, Annika Järviluoma, Sari Jäämaa, Pawan Pyakurel, Christel Pussinen, Maria Wirzenius, Peter Biberfeld, Kari Alitalo, Marikki Laiho, Päivi M Ojala
Publicado 2007

Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.

por Imke Albrecht, Lucie Kopfstein, Karin Strittmatter, Tibor Schomber, Annelie Falkevall, Carolina E Hagberg, Pascal Lorentz, Michael Jeltsch, Kari Alitalo, Ulf Eriksson, Gerhard Christofori, Kristian Pietras
Publicado 2010

Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant

por Ravi Kant, Lauri Kareinen, Teemu Smura, Tobias L. Freitag, Sawan Kumar Jha, Kari Alitalo, Seppo Meri, Tarja Sironen, Kalle Saksela, Tomas Strandin, Anja Kipar, Olli Vapalahti
Publicado 2021

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

por Seon Pyo Hong, Myung Jin Yang, Hyunsoo Cho, Intae Park, Hosung Bae, Kibaek Choe, Sang Heon Suh, Ralf H. Adams, Kari Alitalo, Daesik Lim, Gou Young Koh
Publicado 2020

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

por Ines Martinez-Corral, Yan Zhang, Milena Petkova, Henrik Ortsäter, Sofie Sjöberg, Sandra D. Castillo, Pascal Brouillard, Louis Libbrecht, Dieter Saur, Mariona Graupera, Kari Alitalo, Laurence Boon, Miikka Vikkula, Taija Mäkinen
Publicado 2020

PROX1 is a transcriptional regulator of MMP14

por Silvia Gramolelli, Jianpin Cheng, Ines Martinez-Corral, Markus Vähä-Koskela, Endrit Elbasani, Elisa Kaivanto, Ville Rantanen, Krista Tuohinto, Sampsa Hautaniemi, Mark Bower, Caj Haglund, Kari Alitalo, Taija Mäkinen, Tatiana V. Petrova, Kaisa Lehti, Päivi M. Ojala
Publicado 2018

uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

por Tania Durré, Florent Morfoisse, Charlotte Erpicum, Marie Ebroin, Silvia Blacher, Melissa García-Caballero, Christophe Deroanne, Thomas Louis, Cédric Balsat, Maureen Van de Velde, Seppo Kaijalainen, Frédéric Kridelka, Lars Engelholm, Ingrid Struman, Kari Alitalo, Niels Behrendt, Jenny Paupert, Agnès Noel
Publicado 2018

Anatomy and function of the vertebral column lymphatic network in mice

por Laurent Jacob, Ligia Simoes Braga Boisserand, Luiz Henrique Medeiros Geraldo, Jose de Brito Neto, Thomas Mathivet, Salli Antila, Besma Barka, Yunling Xu, Jean-Mickael Thomas, Juliette Pestel, Marie-Stéphane Aigrot, Eric Song, Harri Nurmi, Seyoung Lee, Kari Alitalo, Nicolas Renier, Anne Eichmann, Jean-Leon Thomas
Publicado 2019

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

por Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Brian Wu, Shweta Varshney, Gonzalo del Monte-Nieto, Zhenwu Zhuang, Rabab Charafeddine, Adam H. Kramer, Nicolas E. Sibinga, Nikolaos G. Frangogiannis, Richard N. Kitsis, Ralf H. Adams, Kari Alitalo, David J. Sharp, Richard P. Harvey, Pamela Stanley, Bin Zhou
Publicado 2017

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

por Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia Formenti, Sandra Demaria, Rajesh K. Soni, Roberta Galarini, Roccaldo Sardella, Gregoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio
Publicado 2021