Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

par Mulki Angela, Yusuke Endo, Hikari K. Asou, Takeshi Yamamoto, Damon J. Tumes, Hirotake Tokuyama, Koutaro Yokote, Toshinori Nakayama
Publié 2016

Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes

par Isao Masuda, Masato Koike, Shohei Nakashima, Yu Mizutani, Yusuke Ozawa, Kenji Watanabe, Yoko Sawada, Hiroshi Sugiyama, Atsushi Sugimoto, Hidetoshi Nojiri, Koichi Sashihara, Koutaro Yokote, Takahiko Shimizu
Publié 2018

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial

par Hironori Nakagami, Ken Sugimoto, Takahiro Ishikawa, Taku Fujimoto, Toshifumi Yamaoka, Misa Hayashi, Eiji Kiyohara, Hiroshi Ando, Yuta Terabe, Yoichi Takami, Koichi Yamamoto, Yasushi Takeya, Minoru Takemoto, Masaya Koshizaka, Tamotsu Ebihara, Ayumi Nakamura, Mitsunori Nishikawa, Xiang Jing Yao, Hideki Hanaoka, Ichiro Katayama, Koutaro Yokote, Hiromi Rakugi
Publié 2018

The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

par Yurie Nagai, Naoya Mimura, Ola Rizq, Yusuke Isshiki, Motohiko Oshima, Mohamed Rizk, Atsunori Saraya, Shuhei Koide, Yaeko Nakajima-Takagi, Makiko Miyota, Tetsuhiro Chiba, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Tohru Iseki, Chiaki Nakaseko, William Lennox, Josephine Sheedy, Marla Weetall, Koutaro Yokote, Atsushi Iwama, Emiko Sakaida
Publié 2021

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

par Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta, Domenica Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, David Figueroa, Marya Morevati, Ho-Joon Lee, Hisaya Kato, Henok Kassahun, Jong-Hyuk Lee, Deborah Filippelli, Mustafa Nazir Okur, Aswin Mangerich, Deborah L. Croteau, Yoshiro Maezawa, Costas A. Lyssiotis, Jun Tao, Koutaro Yokote, Tor Erik Rusten, Mark P. Mattson, Heinrich Jasper, Hilde Nilsen, Vilhelm A. Bohr
Publié 2019

Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis

par Shu-Yang Li, Yoichi Yoshida, Eiichi Kobayashi, Masaaki Kubota, Tomoo Matsutani, Seiichiro Mine, Toshio Machida, Yoshiro Maezawa, Minoru Takemoto, Koutaro Yokote, Yoshio Kobayashi, Hirotaka Takizawa, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Sohei Kobayashi, Kazuyuki Matsushita, Fumio Nomura, Hisahiro Matsubara, Makoto Sumazaki, Masaaki Ito, Satoshi Yajima, Hideaki Shimada, Katsuro Iwase, Hiromi Ashino, Hao Wang, Kenichiro Goto, Go Tomiyoshi, Natsuko Shinmen, Rika Nakamura, Hideyuki Kuroda, Yasuo Iwadate, Takaki Hiwasa
Publié 2021