Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

por Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang
Publicado 2020

Unstable Mechanisms of Resistance to Inhibitors of <named-content content-type="genus-species">Escherichia coli</named-content> Lipoprotein Signal Peptidase

por Homer Pantua, Elizabeth Skippington, Marie-Gabrielle Braun, Cameron L. Noland, Jingyu Diao, Yutian Peng, Susan L. Gloor, Donghong Yan, Jing Kang, Anand Kumar Katakam, Janina Reeder, Georgette M. Castanedo, Keira Garland, Laszlo Komuves, Meredith Sagolla, Cary D. Austin, Jeremy Murray, Yiming Xu, Zora Modrusan, Min Xu, Emily J. Hanan, Sharookh B. Kapadia
Publicado 2020