Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

par Krzysztof Krawczyk, Leo Scheller, Hyojin Kim, Martin Fussenegger
Publié 2020

Designer cells programming quorum-sensing interference with microbes

par Ferdinand Sedlmayer, Dennis Hell, Marius Müller, David Ausländer, Martin Fussenegger
Publié 2018

Phosphoregulated orthogonal signal transduction in mammalian cells

par Leo Scheller, Marc Schmollack, Adrian Bertschi, Maysam Mansouri, Pratik Saxena, Martin Fussenegger
Publié 2020

Caffeine-inducible gene switches controlling experimental diabetes

par Daniel Bojar, Leo Scheller, Ghislaine Charpin-El Hamri, Mingqi Xie, Martin Fussenegger
Publié 2018

Sensing and responding to allergic response cytokines through a genetically encoded circuit

par Hélène Chassin, Barbara Geering, Lina Schukur, David Ausländer, Brian Lang, Martin Fussenegger
Publié 2017

A modular degron library for synthetic circuits in mammalian cells

par Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger
Publié 2019

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

par Pratik Saxena, Boon Chin Heng, Peng Bai, Marc Folcher, Henryk Zulewski, Martin Fussenegger
Publié 2016

Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates

par Nik Franko, Ana Palma Teixeira, Shuai Xue, Ghislaine Charpin-El Hamri, Martin Fussenegger
Publié 2021

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

par Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch, Martin Fussenegger
Publié 2021

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

par Yasunori Okamoto, Ryosuke Kojima, Fabian Schwizer, Eline Bartolami, Tillmann Heinisch, Stefan Matile, Martin Fussenegger, Thomas R. Ward
Publié 2018

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

par Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi, Ghislaine Charpin-El Hamri, Marie Daoud El-Baba, Pratik Saxena, Simon Ausländer, Kelly R. Tan, Martin Fussenegger
Publié 2018