Rewiring of endogenous signaling pathways to genomic targets for therapeutic cell reprogramming

por Krzysztof Krawczyk, Leo Scheller, Hyojin Kim, Martin Fussenegger
Publicado 2020

Designer cells programming quorum-sensing interference with microbes

por Ferdinand Sedlmayer, Dennis Hell, Marius Müller, David Ausländer, Martin Fussenegger
Publicado 2018

Phosphoregulated orthogonal signal transduction in mammalian cells

por Leo Scheller, Marc Schmollack, Adrian Bertschi, Maysam Mansouri, Pratik Saxena, Martin Fussenegger
Publicado 2020

Caffeine-inducible gene switches controlling experimental diabetes

por Daniel Bojar, Leo Scheller, Ghislaine Charpin-El Hamri, Mingqi Xie, Martin Fussenegger
Publicado 2018

Sensing and responding to allergic response cytokines through a genetically encoded circuit

por Hélène Chassin, Barbara Geering, Lina Schukur, David Ausländer, Brian Lang, Martin Fussenegger
Publicado 2017

A modular degron library for synthetic circuits in mammalian cells

por Hélène Chassin, Marius Müller, Marcel Tigges, Leo Scheller, Moritz Lang, Martin Fussenegger
Publicado 2019

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

por Pratik Saxena, Boon Chin Heng, Peng Bai, Marc Folcher, Henryk Zulewski, Martin Fussenegger
Publicado 2016

Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates

por Nik Franko, Ana Palma Teixeira, Shuai Xue, Ghislaine Charpin-El Hamri, Martin Fussenegger
Publicado 2021

Smart-watch-programmed green-light-operated percutaneous control of therapeutic transgenes

por Maysam Mansouri, Marie-Didiée Hussherr, Tobias Strittmatter, Peter Buchmann, Shuai Xue, Gieri Camenisch, Martin Fussenegger
Publicado 2021

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

por Yasunori Okamoto, Ryosuke Kojima, Fabian Schwizer, Eline Bartolami, Tillmann Heinisch, Stefan Matile, Martin Fussenegger, Thomas R. Ward
Publicado 2018

Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment

por Ryosuke Kojima, Daniel Bojar, Giorgio Rizzi, Ghislaine Charpin-El Hamri, Marie Daoud El-Baba, Pratik Saxena, Simon Ausländer, Kelly R. Tan, Martin Fussenegger
Publicado 2018