Exploiting evolutionary steering to induce collateral drug sensitivity in cancer

par Ahmet Acar, Daniel Nichol, Javier Fernandez-Mateos, George D. Cresswell, Iros Barozzi, Sung Pil Hong, Nicholas Trahearn, Inmaculada Spiteri, Mark Stubbs, Rosemary Burke, Adam Stewart, Giulio Caravagna, Benjamin Werner, Georgios Vlachogiannis, Carlo C. Maley, Luca Magnani, Nicola Valeri, Udai Banerji, Andrea Sottoriva
Publié 2020

KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer

par Francesco Sclafani, Ian Chau, David Cunningham, Jens C. Hahne, George Vlachogiannis, Zakaria Eltahir, Andrea Lampis, Chiara Braconi, Eleftheria Kalaitzaki, David Gonzalez De Castro, Andrew Wotherspoon, Jaume Capdevila, Bengt Glimelius, Noelia Tarazona, Ruwaida Begum, Hazel Lote, Sanna Hulkki Wilson, Giulia Mentrasti, Gina Brown, Diana Tait, Jacqueline Oates, Nicola Valeri
Publié 2018

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

par Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Publié 2021

Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage

par Pietro Carotenuto, Francesco Amato, Andrea Lampis, Colin Rae, Somaieh Hedayat, Maria C. Previdi, Domenico Zito, Maya Raj, Vincenza Guzzardo, Francesco Sclafani, Andrea Lanese, Claudia Parisi, Caterina Vicentini, Ian Said-Huntingford, Jens C. Hahne, Albert Hallsworth, Vladimir Kirkin, Kate Young, Ruwaida Begum, Andrew Wotherspoon, Kyriakos Kouvelakis, Sergio Xavier Azevedo, Vasiliki Michalarea, Rosie Upstill-Goddard, Sheela Rao, David Watkins, Naureen Starling, Anguraj Sadanandam, David K. Chang, Andrew V. Biankin, Nigel B. Jamieson, Aldo Scarpa, David Cunningham, Ian Chau, Paul Workman, Matteo Fassan, Nicola Valeri, Chiara Braconi
Publié 2021