Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

por Anne-Marinette Cao, Robert B. Quast, Fataneh Fatemi, Philippe Rondard, Jean-Philippe Pin, Emmanuel Margeat
Publicado 2021

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

por Li Xue, Qian Sun, Han Zhao, Xavier Rovira, Siyu Gai, Qianwen He, Jean-Philippe Pin, Jianfeng Liu, Philippe Rondard
Publicado 2019

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

por Bo Wei, Yini Zhu, Peng Yang, Yong Han, Suyun Wang, Xiaomei Wang, Shuai Xia, Xiaoguang Song, Zhongling Zhang, Sheng Wang, Philippe Rondard, Jean-Philippe Pin, Xinnong Jiang, Jianfeng Liu
Publicado 2021

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation

por Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C. Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin
Publicado 2017