A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

by Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M. Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webber
Published 2020

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

by Walther Haenseler, Federico Zambon, Heyne Lee, Jane Vowles, Federica Rinaldi, Galbha Duggal, Henry Houlden, Katrina Gwinn, Selina Wray, Kelvin C. Luk, Richard Wade-Martins, William S. James, Sally A. Cowley
Published 2017

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

by Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Published 2020

CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease

by Nora Bengoa-Vergniory, Emilie Faggiani, Paula Ramos-Gonzalez, Ecem Kirkiz, Natalie Connor-Robson, Liam V. Brown, Ibrar Siddique, Zizheng Li, Siv Vingill, Milena Cioroch, Fabio Cavaliere, Sarah Threlfell, Bradley Roberts, Thomas Schrader, Frank-Gerrit Klärner, Stephanie Cragg, Benjamin Dehay, Gal Bitan, Carlos Matute, Erwan Bezard, Richard Wade-Martins
Published 2020

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

by Julia Benkert, Simon Hess, Shoumik Roy, Dayne Beccano-Kelly, Nicole Wiederspohn, Johanna Duda, Carsten Simons, Komal Patil, Aisylu Gaifullina, Nadja Mannal, Elena Dragicevic, Desirée Spaich, Sonja Müller, Julia Nemeth, Helene Hollmann, Nora Deuter, Yassine Mousba, Christian Kubisch, Christina Poetschke, Joerg Striessnig, Olaf Pongs, Toni Schneider, Richard Wade-Martins, Sandip Patel, Rosanna Parlato, Tobias Frank, Peter Kloppenburg, Birgit Liss
Published 2019