Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status.

por Gillian Farnie, Pamela M Willan, Robert B Clarke, Nigel J Bundred
Publicado 2013

Wnt pathway activity in breast cancer sub-types and stem-like cells.

por Rebecca Lamb, Matthew P Ablett, Katherine Spence, Göran Landberg, Andrew H Sims, Robert B Clarke
Publicado 2013

Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model.

por Zvia Agur, Oleg U Kirnasovsky, Genadiy Vasserman, Lilach Tencer-Hershkowicz, Yuri Kogan, Hannah Harrison, Rebecca Lamb, Robert B Clarke
Publicado 2011

FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

por Simon Timbrell, Hosam Aglan, Angela Cramer, Phil Foden, David Weaver, Jonathan Pachter, Aoife Kilgallon, Robert B. Clarke, Gillian Farnie, Nigel J. Bundred
Publicado 2021

Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

por Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Publicado 2021

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

por Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke
Publicado 2019