Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5α specificity.

por Kevin R McCarthy, Aaron G Schmidt, Andrea Kirmaier, Allison L Wyand, Ruchi M Newman, Welkin E Johnson
Publicado 2013

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

por Andrea Kirmaier, Fan Wu, Ruchi M Newman, Laura R Hall, Jennifer S Morgan, Shelby O'Connor, Preston A Marx, Mareike Meythaler, Simoy Goldstein, Alicia Buckler-White, Amitinder Kaur, Vanessa M Hirsch, Welkin E Johnson
Publicado 2010