A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

por Nuria Suelves, Lucy Kirkham-McCarthy, Robert S. Lahue, Silvia Ginés
Publicado 2017

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

por Albert Giralt, Veronica Brito, Quentin Chevy, Clémence Simonnet, Yo Otsu, Carmen Cifuentes-Díaz, Benoit de Pins, Renata Coura, Jordi Alberch, Sílvia Ginés, Jean-Christophe Poncer, Jean-Antoine Girault
Publicado 2017

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

por Manuel Daldin, Valentina Fodale, Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi, Maria Carolina Spiezia, Sean M. Deguire, Marta Cherubini, Douglas Macdonald, Andreas Weiss, Alberto Bresciani, Jean-Paul Gerard Vonsattel, Lara Petricca, J. Lawrence Marsh, Silvia Gines, Iolanda Santimone, Massimo Marano, Hilal A. Lashuel, Ferdinando Squitieri, Andrea Caricasole
Publicado 2017