Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes

par Karolina Gherbi, Stephen J. Briddon, Steven J. Charlton
Publié 2018

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

par David A. Sykes, J. Robert Lane, Monika Szabo, Ben Capuano, Jonathan A. Javitch, Steven J. Charlton
Publié 2018

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

par David A. Sykes, Holly Moore, Lisa Stott, Nicholas Holliday, Jonathan A. Javitch, J. Robert Lane, Steven J. Charlton
Publié 2017

The role of kinetic context in apparent biased agonism at GPCRs

par Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti, Meritxell Canals, Thomas Coudrat, Jeremy Shonberg, Peter J. Scammells, Ben Capuano, Patrick M. Sexton, Steven J. Charlton, Jonathan A. Javitch, Arthur Christopoulos, J. Robert Lane
Publié 2016