SPA70 is a potent antagonist of human pregnane X receptor

par Wenwei Lin, Yue-Ming Wang, Sergio C. Chai, Lili Lv, Jie Zheng, Jing Wu, Qijun Zhang, Yong-Dong Wang, Patrick R. Griffin, Taosheng Chen
Publié 2017

Transcription factor ZNF148 is a negative regulator of human muscle differentiation

par Jesse Bakke, William C. Wright, Anthony E. Zamora, Su Sien Ong, Yue-Ming Wang, Jessica D. Hoyer, Christopher T. Brewer, Paul G. Thomas, Taosheng Chen
Publié 2017

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

par Seung Wook Yang, Xin Huang, Wenwei Lin, Jaeki Min, Darcie J. Miller, Anand Mayasundari, Patrick Rodrigues, Elizabeth C. Griffith, Clifford T. Gee, Lei Li, Wei Li, Richard E. Lee, Zoran Rankovic, Taosheng Chen, Patrick Ryan Potts
Publié 2020

An unexpected protein interaction promotes drug resistance in leukemia

par Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz
Publié 2017

A phosphotyrosine switch regulates organic cation transporters

par Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Shuiying Hu, Guoqing Du, Wenwei Lin, Lie Li, Shashank Bharill, Rachel A. Ness, Adrian Stecula, Steven M. Offer, Robert B. Diasio, Anne T. Nies, Matthias Schwab, Guido Cavaletti, Eberhard Schlatter, Giuliano Ciarimboli, Jan H. M. Schellens, Ehud Y. Isacoff, Andrej Sali, Taosheng Chen, Sharyn D. Baker, Alex Sparreboom, Navjotsingh Pabla
Publié 2016

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

par Ji Young Kim, Yuntao Bai, Laura A. Jayne, Ralph D. Hector, Avinash K. Persaud, Su Sien Ong, Shreshtha Rojesh, Radhika Raj, Mei Ji He Ho Feng, Sangwoon Chung, Rachel E. Cianciolo, John W. Christman, Moray J. Campbell, David S. Gardner, Sharyn D. Baker, Alex Sparreboom, Rajgopal Govindarajan, Harpreet Singh, Taosheng Chen, Ming Poi, Katalin Susztak, Stuart R. Cobb, Navjot Singh Pabla
Publié 2020

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

par Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publié 2021

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

par Chen He, Ke Xu, Xiaoyan Zhu, Paige S. Dunphy, Brian Gudenas, Wenwei Lin, Nathaniel Twarog, Laura D. Hover, Chang-Hyuk Kwon, Lawryn H. Kasper, Junyuan Zhang, Xiaoyu Li, James Dalton, Barbara Jonchere, Kimberly S. Mercer, Duane G. Currier, William Caufield, Yingzhe Wang, Jia Xie, Alberto Broniscer, Cynthia Wetmore, Santhosh A. Upadhyaya, Ibrahim Qaddoumi, Paul Klimo, Frederick Boop, Amar Gajjar, Jinghui Zhang, Brent A. Orr, Giles W. Robinson, Michelle Monje, Burgess B. Freeman III, Martine F. Roussel, Paul A. Northcott, Taosheng Chen, Zoran Rankovic, Gang Wu, Jason Chiang, Christopher L. Tinkle, Anang A. Shelat, Suzanne J. Baker
Publié 2021