Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication

par Lily E. Adams, Kenneth H. Dinnon, Yixuan J. Hou, Timothy P. Sheahan, Mark T. Heise, Ralph S. Baric
Publié 2021

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

par Lisa E. Gralinski, Timothy P. Sheahan, Thomas E. Morrison, Vineet D. Menachery, Kara Jensen, Sarah R. Leist, Alan Whitmore, Mark T. Heise, Ralph S. Baric
Publié 2018

Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion

par Lisa C. Lindesmith, Michael L. Mallory, Kari Debbink, Eric F. Donaldson, Paul D. Brewer-Jensen, Excel W. Swann, Timothy P. Sheahan, Rachel L. Graham, Martina Beltramello, Davide Corti, Antonio Lanzavecchia, Ralph S. Baric
Publié 2018

Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

par Amy C. Sims, Hugh D. Mitchell, Lisa E. Gralinski, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Mariam Lam, M. Leslie Fulcher, Ande West, Richard D. Smith, Scott H. Randell, Thomas O. Metz, Timothy P. Sheahan, Katrina M. Waters, Ralph S. Baric
Publié 2021

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

par Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison
Publié 2018

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

par Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Publié 2020