Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells

por Tamara Heintze, Kathrin Klein, Ute Hofmann, Ulrich M. Zanger
Publicado 2021

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

por Anne T Nies, Ute Hofmann, Claudia Resch, Elke Schaeffeler, Maria Rius, Matthias Schwab
Publicado 2011

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

por Tamara Heintze, Tamara Heintze, Denise Wilhelm, Thierry Schmidlin, Thierry Schmidlin, Thierry Schmidlin, Ute Hofmann, Ute Hofmann, Ulrich M. Zanger, Ulrich M. Zanger, Matthias Schwab, Matthias Schwab, Matthias Schwab, Kathrin Klein, Kathrin Klein
Publicado 2021

Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.

por Michael A Dengler, Annette M Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak, Peter Scheurich, Matthias Schwab, Walter E Aulitzky, Heiko van der Kuip
Publicado 2011

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

por Arne Schenk, Ahmed Ghallab, Ute Hofmann, Reham Hassan, Michael Schwarz, Andreas Schuppert, Lars Ole Schwen, Albert Braeuning, Donato Teutonico, Jan G. Hengstler, Lars Kuepfer
Publicado 2017

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations

por Markus Krauss, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert, Michael Block, Elke Schaeffeler, Gabriele Boehmer, Linus Goerlitz, Jan Hoecker, Joerg Lippert, Reinhold Kerb, Jochen Hampe, Lars Kuepfer, Matthias Schwab
Publicado 2017