Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma

por Myung-Chul Kim, Zeng Jin, Ryan Kolb, Nicholas Borcherding, Jonathan Alexander Chatzkel, Sara Moscovita Falzarano, Weizhou Zhang
Publicado 2021

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

por Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K. Salem, Russell W. Jenkins, Yousef Zakharia, Weizhou Zhang
Publicado 2021

The GPR171 pathway suppresses T cell activation and limits antitumor immunity

por Yuki Fujiwara, Robert J. Torphy, Yi Sun, Emily N. Miller, Felix Ho, Nicholas Borcherding, Tuoqi Wu, Raul M. Torres, Weizhou Zhang, Richard D. Schulick, Yuwen Zhu
Publicado 2021

Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells

por Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang
Publicado 2021

Obesity-associated NLRC4 inflammasome activation drives breast cancer progression

por Ryan Kolb, Liem Phan, Nicholas Borcherding, Yinghong Liu, Fang Yuan, Ann M. Janowski, Qing Xie, Kathleen R. Markan, Wei Li, Matthew J. Potthoff, Enrique Fuentes-Mattei, Lesley G. Ellies, C. Michael Knudson, Mong-Hong Lee, Sai-Ching J. Yeung, Suzanne L. Cassel, Fayyaz S. Sutterwala, Weizhou Zhang
Publicado 2016

Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

por Dongwen Lv, Pratik Pal, Xingui Liu, Yannan Jia, Dinesh Thummuri, Peiyi Zhang, Wanyi Hu, Jing Pei, Qi Zhang, Shuo Zhou, Sajid Khan, Xuan Zhang, Nan Hua, Qingping Yang, Sebastian Arango, Weizhou Zhang, Digant Nayak, Shaun K. Olsen, Susan T. Weintraub, Robert Hromas, Marina Konopleva, Yaxia Yuan, Guangrong Zheng, Daohong Zhou
Publicado 2021

CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells

por Myung-Chul Kim, Nicholas Borcherding, Kawther K. Ahmed, Andrew P. Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N. Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y. Helm, Xin Zhang, Katherine N. Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
Publicado 2021