Structure and transport mechanism of P5B-ATPases

In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate transport cycle...

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Autores principales: Ping Li, Kaituo Wang, Nina Salustros, Christina Grønberg, Pontus Gourdon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0006c973873742fca619d15d27702bd7
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