Structure and transport mechanism of P5B-ATPases

In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate transport cycle...

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Autores principales:	Ping Li, Kaituo Wang, Nina Salustros, Christina Grønberg, Pontus Gourdon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0006c973873742fca619d15d27702bd7
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id	oai:doaj.org-article:0006c973873742fca619d15d27702bd7
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spelling	oai:doaj.org-article:0006c973873742fca619d15d27702bd72021-12-02T16:06:03ZStructure and transport mechanism of P5B-ATPases10.1038/s41467-021-24148-y2041-1723https://doaj.org/article/0006c973873742fca619d15d27702bd72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24148-yhttps://doaj.org/toc/2041-1723In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate transport cycle intermediates, including spermine‐bound conformationsPing LiKaituo WangNina SalustrosChristina GrønbergPontus GourdonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping Li Kaituo Wang Nina Salustros Christina Grønberg Pontus Gourdon Structure and transport mechanism of P5B-ATPases
description	In human cells, P5B‐ATPases execute export of spermine from lysosomes to the cytosol, but the mechanisms of spermine recognition, uptake and transport remain elusive. Here the authors present cryo‐EM structures of a yeast homolog of human ATP13A2‐5, Ypk9, which depict three separate transport cycle intermediates, including spermine‐bound conformations
format	article
author	Ping Li Kaituo Wang Nina Salustros Christina Grønberg Pontus Gourdon
author_facet	Ping Li Kaituo Wang Nina Salustros Christina Grønberg Pontus Gourdon
author_sort	Ping Li
title	Structure and transport mechanism of P5B-ATPases
title_short	Structure and transport mechanism of P5B-ATPases
title_full	Structure and transport mechanism of P5B-ATPases
title_fullStr	Structure and transport mechanism of P5B-ATPases
title_full_unstemmed	Structure and transport mechanism of P5B-ATPases
title_sort	structure and transport mechanism of p5b-atpases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0006c973873742fca619d15d27702bd7
work_keys_str_mv	AT pingli structureandtransportmechanismofp5batpases AT kaituowang structureandtransportmechanismofp5batpases AT ninasalustros structureandtransportmechanismofp5batpases AT christinagrønberg structureandtransportmechanismofp5batpases AT pontusgourdon structureandtransportmechanismofp5batpases
_version_	1718385126196379648

Structure and transport mechanism of P5B-ATPases

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