A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment

How haematopoietic and endothelial cell lineages are specified is unclear. Here, the authors identify the forkhead transcription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.

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Autores principales: Haiyong Zhao, Kyunghee Choi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/00255555629444c58237c9fbd7ac5235
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