A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment

How haematopoietic and endothelial cell lineages are specified is unclear. Here, the authors identify the forkhead transcription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.

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Autores principales:	Haiyong Zhao, Kyunghee Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00255555629444c58237c9fbd7ac5235
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spelling	oai:doaj.org-article:00255555629444c58237c9fbd7ac52352021-12-02T15:37:06ZA CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment10.1038/s41467-017-00667-52041-1723https://doaj.org/article/00255555629444c58237c9fbd7ac52352017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00667-5https://doaj.org/toc/2041-1723How haematopoietic and endothelial cell lineages are specified is unclear. Here, the authors identify the forkhead transcription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.Haiyong ZhaoKyunghee ChoiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haiyong Zhao Kyunghee Choi A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment
description	How haematopoietic and endothelial cell lineages are specified is unclear. Here, the authors identify the forkhead transcription factor Foxh1 as regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangiogenic fate via Etv2.
format	article
author	Haiyong Zhao Kyunghee Choi
author_facet	Haiyong Zhao Kyunghee Choi
author_sort	Haiyong Zhao
title	A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment
title_short	A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment
title_full	A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment
title_fullStr	A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment
title_full_unstemmed	A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment
title_sort	crispr screen identifies genes controlling etv2 threshold expression in murine hemangiogenic fate commitment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00255555629444c58237c9fbd7ac5235
work_keys_str_mv	AT haiyongzhao acrisprscreenidentifiesgenescontrollingetv2thresholdexpressioninmurinehemangiogenicfatecommitment AT kyungheechoi acrisprscreenidentifiesgenescontrollingetv2thresholdexpressioninmurinehemangiogenicfatecommitment AT haiyongzhao crisprscreenidentifiesgenescontrollingetv2thresholdexpressioninmurinehemangiogenicfatecommitment AT kyungheechoi crisprscreenidentifiesgenescontrollingetv2thresholdexpressioninmurinehemangiogenicfatecommitment
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A CRISPR screen identifies genes controlling Etv2 threshold expression in murine hemangiogenic fate commitment

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