Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD

Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RI...

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Bibliographic Details
Main Authors: Wei Lin, Jing Zhang, Haiyan Lin, Zexing Li, Xiaofeng Sun, Di Xin, Meng Yang, Liwei Sun, Lin Li, Hongmei Wang, Dahua Chen, Qinmiao Sun
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/005dc6f1a7ee4f02bb86db514a26a462
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Summary:Syndecans are transmembrane proteoglycans implicated in diverse cellular activities. Here the authors show that Syndecan-4 via its cytosolic domain negatively regulates antiviral immunity by enhancing RIG-I interaction with a deubiquitinating enzyme CYLD, thus inhibiting the activating K63-linked RIG-I ubiquitination.

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