Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes

Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes

Abstract An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which suppresses tumorigenesis via a number of different mechanisms. Approximately 45% of non-small cell lung cancers (NSCLC) are deficient in LIMD1, y...

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Main Authors: Kathryn Davidson, Paul Grevitt, Maria F. Contreras-Gerenas, Katherine S. Bridge, Miguel Hermida, Kunal M. Shah, Faraz K. Mardakheh, Mark Stubbs, Rosemary Burke, Pedro Casado, Pedro R. Cutillas, Sarah A. Martin, Tyson V. Sharp
Format: article
Language:EN
Published: Nature Publishing Group 2021
Subjects:
Cytology
QH573-671
Online Access:https://doaj.org/article/006a5cc989ef440e83fa93a4ded65708
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https://doaj.org/article/006a5cc989ef440e83fa93a4ded65708

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