Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing

Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose existing approved drugs for clinical interventions. Here, the authors identify robust druggable protein targets within a principled causal framework that makes use of multiple data modalities and integrates agin...

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Bibliographic Details
Main Authors: Anastasiya Belyaeva, Louis Cammarata, Adityanarayanan Radhakrishnan, Chandler Squires, Karren Dai Yang, G. V. Shivashankar, Caroline Uhler
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/0070bbeebfbc43a1a7a2f2bff257da7c
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