Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent...
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Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/00865757a5f04af799714d7f5969a1fd |
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