Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent...

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Autores principales:	Jia-Lin Huang, Gan Jiang, Qing-Xiang Song, Xiao Gu, Meng Hu, Xiao-Lin Wang, Hua-Hua Song, Le-Pei Chen, Ying-Ying Lin, Di Jiang, Jun Chen, Jun-Feng Feng, Yong-Ming Qiu, Ji-Yao Jiang, Xin-Guo Jiang, Hong-Zhuan Chen, Xiao-Ling Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00865757a5f04af799714d7f5969a1fd
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spelling	oai:doaj.org-article:00865757a5f04af799714d7f5969a1fd2021-12-02T17:01:18ZLipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis10.1038/ncomms151442041-1723https://doaj.org/article/00865757a5f04af799714d7f5969a1fd2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15144https://doaj.org/toc/2041-1723Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent manner.Jia-Lin HuangGan JiangQing-Xiang SongXiao GuMeng HuXiao-Lin WangHua-Hua SongLe-Pei ChenYing-Ying LinDi JiangJun ChenJun-Feng FengYong-Ming QiuJi-Yao JiangXin-Guo JiangHong-Zhuan ChenXiao-Ling GaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia-Lin Huang Gan Jiang Qing-Xiang Song Xiao Gu Meng Hu Xiao-Lin Wang Hua-Hua Song Le-Pei Chen Ying-Ying Lin Di Jiang Jun Chen Jun-Feng Feng Yong-Ming Qiu Ji-Yao Jiang Xin-Guo Jiang Hong-Zhuan Chen Xiao-Ling Gao Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
description	Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent manner.
format	article
author	Jia-Lin Huang Gan Jiang Qing-Xiang Song Xiao Gu Meng Hu Xiao-Lin Wang Hua-Hua Song Le-Pei Chen Ying-Ying Lin Di Jiang Jun Chen Jun-Feng Feng Yong-Ming Qiu Ji-Yao Jiang Xin-Guo Jiang Hong-Zhuan Chen Xiao-Ling Gao
author_facet	Jia-Lin Huang Gan Jiang Qing-Xiang Song Xiao Gu Meng Hu Xiao-Lin Wang Hua-Hua Song Le-Pei Chen Ying-Ying Lin Di Jiang Jun Chen Jun-Feng Feng Yong-Ming Qiu Ji-Yao Jiang Xin-Guo Jiang Hong-Zhuan Chen Xiao-Ling Gao
author_sort	Jia-Lin Huang
title	Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
title_short	Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
title_full	Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
title_fullStr	Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
title_full_unstemmed	Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
title_sort	lipoprotein-biomimetic nanostructure enables efficient targeting delivery of sirna to ras-activated glioblastoma cells via macropinocytosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/00865757a5f04af799714d7f5969a1fd
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Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

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