Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

Drug delivery in brain tumours is still a significant clinical concern. In this study, the authors develop a biomimetic lipoprotein nanoparticle for the efficient delivery of ATF5 siRNA inRas-activated brain cancer cells, where the nanoparticle is internalized by macropinocytosis in a Ras-dependent...

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Autores principales: Jia-Lin Huang, Gan Jiang, Qing-Xiang Song, Xiao Gu, Meng Hu, Xiao-Lin Wang, Hua-Hua Song, Le-Pei Chen, Ying-Ying Lin, Di Jiang, Jun Chen, Jun-Feng Feng, Yong-Ming Qiu, Ji-Yao Jiang, Xin-Guo Jiang, Hong-Zhuan Chen, Xiao-Ling Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/00865757a5f04af799714d7f5969a1fd
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