Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.

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Autores principales:	Markus Schmid, Patrick Ernst, Annemarie Honegger, Maarit Suomalainen, Martina Zimmermann, Lukas Braun, Sarah Stauffer, Cristian Thom, Birgit Dreier, Matthias Eibauer, Anja Kipar, Viola Vogel, Urs F. Greber, Ohad Medalia, Andreas Plückthun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00949421a2154bc48f4b16eaea93bece
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spelling	oai:doaj.org-article:00949421a2154bc48f4b16eaea93bece2021-12-02T14:40:30ZAdenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control10.1038/s41467-017-02707-62041-1723https://doaj.org/article/00949421a2154bc48f4b16eaea93bece2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02707-6https://doaj.org/toc/2041-1723Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.Markus SchmidPatrick ErnstAnnemarie HoneggerMaarit SuomalainenMartina ZimmermannLukas BraunSarah StaufferCristian ThomBirgit DreierMatthias EibauerAnja KiparViola VogelUrs F. GreberOhad MedaliaAndreas PlückthunNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Markus Schmid Patrick Ernst Annemarie Honegger Maarit Suomalainen Martina Zimmermann Lukas Braun Sarah Stauffer Cristian Thom Birgit Dreier Matthias Eibauer Anja Kipar Viola Vogel Urs F. Greber Ohad Medalia Andreas Plückthun Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
description	Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.
format	article
author	Markus Schmid Patrick Ernst Annemarie Honegger Maarit Suomalainen Martina Zimmermann Lukas Braun Sarah Stauffer Cristian Thom Birgit Dreier Matthias Eibauer Anja Kipar Viola Vogel Urs F. Greber Ohad Medalia Andreas Plückthun
author_facet	Markus Schmid Patrick Ernst Annemarie Honegger Maarit Suomalainen Martina Zimmermann Lukas Braun Sarah Stauffer Cristian Thom Birgit Dreier Matthias Eibauer Anja Kipar Viola Vogel Urs F. Greber Ohad Medalia Andreas Plückthun
author_sort	Markus Schmid
title	Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
title_short	Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
title_full	Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
title_fullStr	Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
title_full_unstemmed	Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
title_sort	adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/00949421a2154bc48f4b16eaea93bece
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Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

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