Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.

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Bibliographic Details
Main Authors: Markus Schmid, Patrick Ernst, Annemarie Honegger, Maarit Suomalainen, Martina Zimmermann, Lukas Braun, Sarah Stauffer, Cristian Thom, Birgit Dreier, Matthias Eibauer, Anja Kipar, Viola Vogel, Urs F. Greber, Ohad Medalia, Andreas Plückthun
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/00949421a2154bc48f4b16eaea93bece
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Internet

https://doaj.org/article/00949421a2154bc48f4b16eaea93bece

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