Glu-108 in <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Rad51 Is Critical for DNA Damage-Induced Nuclear Function

Glu-108 in <named-content content-type="genus-species">Saccharomyces cerevisiae</named-content> Rad51 Is Critical for DNA Damage-Induced Nuclear Function

ABSTRACT DNA damage-induced Rad51 focus formation is the hallmark of homologous recombination-mediated DNA repair. Earlier, we reported that Rad51 physically interacts with Hsp90, and under the condition of Hsp90 inhibition, it undergoes proteasomal degradation. Here, we show that the dynamic intera...

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Autores principales: Tanvi Suhane, Vijayalakshmi Bindumadhavan, Nupur Fangaria, Achuthsankar S. Nair, Wahida Tabassum, Poorvaja Muley, Mrinal K. Bhattacharyya, Sunanda Bhattacharyya
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
DNA repair
Hsp90
homologous recombination
Hsp90-Rad51 interaction
Rad51 recruitment to chromatin
molecular chaperone
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/009f715e844c4827b1572413eed3db8f
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https://doaj.org/article/009f715e844c4827b1572413eed3db8f

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