Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

Some ion channels are modulated by binding of cyclic nucleotide to a cyclic nucleotide-binding domain. Here, the authors use high-speed atomic force microscopy to directly monitor the conformational changes induced by ligand binding to a cyclic nucleotide-modulated channel from Mesorhizobium loti.

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Autores principales: Martina Rangl, Atsushi Miyagi, Julia Kowal, Henning Stahlberg, Crina M. Nimigean, Simon Scheuring
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/00cdeb3d89d7440fa91c5c72fa6ce7e5
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