Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

Some ion channels are modulated by binding of cyclic nucleotide to a cyclic nucleotide-binding domain. Here, the authors use high-speed atomic force microscopy to directly monitor the conformational changes induced by ligand binding to a cyclic nucleotide-modulated channel from Mesorhizobium loti.

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Autores principales:	Martina Rangl, Atsushi Miyagi, Julia Kowal, Henning Stahlberg, Crina M. Nimigean, Simon Scheuring
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/00cdeb3d89d7440fa91c5c72fa6ce7e5
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spelling	oai:doaj.org-article:00cdeb3d89d7440fa91c5c72fa6ce7e52021-12-02T17:33:06ZReal-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels10.1038/ncomms127892041-1723https://doaj.org/article/00cdeb3d89d7440fa91c5c72fa6ce7e52016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12789https://doaj.org/toc/2041-1723Some ion channels are modulated by binding of cyclic nucleotide to a cyclic nucleotide-binding domain. Here, the authors use high-speed atomic force microscopy to directly monitor the conformational changes induced by ligand binding to a cyclic nucleotide-modulated channel from Mesorhizobium loti.Martina RanglAtsushi MiyagiJulia KowalHenning StahlbergCrina M. NimigeanSimon ScheuringNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martina Rangl Atsushi Miyagi Julia Kowal Henning Stahlberg Crina M. Nimigean Simon Scheuring Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
description	Some ion channels are modulated by binding of cyclic nucleotide to a cyclic nucleotide-binding domain. Here, the authors use high-speed atomic force microscopy to directly monitor the conformational changes induced by ligand binding to a cyclic nucleotide-modulated channel from Mesorhizobium loti.
format	article
author	Martina Rangl Atsushi Miyagi Julia Kowal Henning Stahlberg Crina M. Nimigean Simon Scheuring
author_facet	Martina Rangl Atsushi Miyagi Julia Kowal Henning Stahlberg Crina M. Nimigean Simon Scheuring
author_sort	Martina Rangl
title	Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
title_short	Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
title_full	Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
title_fullStr	Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
title_full_unstemmed	Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels
title_sort	real-time visualization of conformational changes within single mlok1 cyclic nucleotide-modulated channels
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/00cdeb3d89d7440fa91c5c72fa6ce7e5
work_keys_str_mv	AT martinarangl realtimevisualizationofconformationalchangeswithinsinglemlok1cyclicnucleotidemodulatedchannels AT atsushimiyagi realtimevisualizationofconformationalchangeswithinsinglemlok1cyclicnucleotidemodulatedchannels AT juliakowal realtimevisualizationofconformationalchangeswithinsinglemlok1cyclicnucleotidemodulatedchannels AT henningstahlberg realtimevisualizationofconformationalchangeswithinsinglemlok1cyclicnucleotidemodulatedchannels AT crinamnimigean realtimevisualizationofconformationalchangeswithinsinglemlok1cyclicnucleotidemodulatedchannels AT simonscheuring realtimevisualizationofconformationalchangeswithinsinglemlok1cyclicnucleotidemodulatedchannels
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Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

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