Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells

Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells

Abstract Background In recent years, several hundred autism spectrum disorder (ASD) implicated genes have been discovered impacting a wide range of molecular pathways. However, the molecular underpinning of ASD, particularly from the point of view of ‘brain to behaviour’ pathogenic mechanisms, remai...

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Autores principales: Nasna Nassir, Asma Bankapur, Bisan Samara, Abdulrahman Ali, Awab Ahmed, Ibrahim M. Inuwa, Mehdi Zarrei, Seyed Ali Safizadeh Shabestari, Ammar AlBanna, Jennifer L. Howe, Bakhrom K. Berdiev, Stephen W. Scherer, Marc Woodbury-Smith, Mohammed Uddin
Formato: article
Lenguaje:EN
Publicado: BMC 2021
Materias:
Single-cell transcriptomics
Autism spectrum disorder
De novo LOF variant
Glial cell type
Brain tissue
Medicine
R
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/00dc4650ae5a4c8da8d8c168cea1f017
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https://doaj.org/article/00dc4650ae5a4c8da8d8c168cea1f017

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