A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo

Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate intracellular Ca2+ levels in in vivo neural c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Josh D. Hawk, Elias M. Wisdom, Titas Sengupta, Zane D. Kashlan, Daniel A. Colón-Ramos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/011bbc5d4fc94de3b2244cd6f41fc519
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:011bbc5d4fc94de3b2244cd6f41fc519
record_format	dspace
spelling	oai:doaj.org-article:011bbc5d4fc94de3b2244cd6f41fc5192021-12-02T18:50:44ZA genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo10.1038/s41467-021-24690-92041-1723https://doaj.org/article/011bbc5d4fc94de3b2244cd6f41fc5192021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24690-9https://doaj.org/toc/2041-1723Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate intracellular Ca2+ levels in in vivo neural circuits.Josh D. HawkElias M. WisdomTitas SenguptaZane D. KashlanDaniel A. Colón-RamosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Josh D. Hawk Elias M. Wisdom Titas Sengupta Zane D. Kashlan Daniel A. Colón-Ramos A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
description	Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate intracellular Ca2+ levels in in vivo neural circuits.
format	article
author	Josh D. Hawk Elias M. Wisdom Titas Sengupta Zane D. Kashlan Daniel A. Colón-Ramos
author_facet	Josh D. Hawk Elias M. Wisdom Titas Sengupta Zane D. Kashlan Daniel A. Colón-Ramos
author_sort	Josh D. Hawk
title	A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
title_short	A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
title_full	A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
title_fullStr	A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
title_full_unstemmed	A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
title_sort	genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/011bbc5d4fc94de3b2244cd6f41fc519
work_keys_str_mv	AT joshdhawk ageneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT eliasmwisdom ageneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT titassengupta ageneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT zanedkashlan ageneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT danielacolonramos ageneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT joshdhawk geneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT eliasmwisdom geneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT titassengupta geneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT zanedkashlan geneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo AT danielacolonramos geneticallyencodedtoolforreconstitutingsyntheticmodulatoryneurotransmissionandreconnectneuralcircuitsinvivo
_version_	1718377484010913792

A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo

Ejemplares similares