High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation

Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals within 10 weeks of ch...

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Bibliographic Details
Main Authors:	Laura Sibley, Andrew D. White, Karen E. Gooch, Lisa M. Stevens, Rachel Tanner, Ashley Jacobs, Owen Daykin-Pont, Fergus Gleeson, Anthony McIntyre, Randall Basaraba, Simon Clark, Graham Hall, Geoff Pearson, Emma Rayner, Helen McShane, Ann Williams, Mike Dennis, Philip D. Marsh, Sally Sharpe
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/012f7b94a99f4b9a8b55500c6bbff3f8
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High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation

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