Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates. Here, the authors elucidate the cellular roles and substrates of these polymerases using comparative functional and proteomic...

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Bibliographic Details
Main Authors: Amit Bhardwaj, Yanling Yang, Beatrix Ueberheide, Susan Smith
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/013778b4668542dcb7be9914663032bd
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