A lipid receptor sorts polyomavirus from the endolysosome to the endoplasmic reticulum to cause infection.

The mechanisms by which receptors guide intracellular virus transport are poorly characterized. The murine polyomavirus (Py) binds to the lipid receptor ganglioside GD1a and traffics to the endoplasmic reticulum (ER) where it enters the cytosol and then the nucleus to initiate infection. How Py reac...

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Bibliographic Details
Main Authors: Mengding Qian, Dawen Cai, Kristen J Verhey, Billy Tsai
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
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Online Access:https://doaj.org/article/01529c43d05943af82ac3cdb72d437d0
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